1. Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men.
- Author
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Scully E, Lockhart A, Huang L, Robles Y, Becerril C, Romero-Tejeda M, Albrecht MA, Palmer CD, Bosch RJ, Altfeld M, Kuritzkes DR, and Lin NH
- Subjects
- Adult, Biomarkers, Chemokine CCL2 genetics, Genotype, HIV Infections virology, Humans, Immunity, Innate physiology, Inflammation metabolism, Lymphocyte Activation, Male, Middle Aged, T-Lymphocytes physiology, Aging, Anti-HIV Agents therapeutic use, Bacterial Translocation physiology, Chemokine CCL2 metabolism, HIV Infections metabolism, HIV-1
- Abstract
The aging of the human immunodeficiency virus type 1 (HIV-1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤ 35 years or ≥ 50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression., (© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)
- Published
- 2016
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