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Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2016 Mar 01; Vol. 213 (5), pp. 771-5. Date of Electronic Publication: 2015 Oct 22. - Publication Year :
- 2016
-
Abstract
- The aging of the human immunodeficiency virus type 1 (HIV-1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤ 35 years or ≥ 50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.<br /> (© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)
- Subjects :
- Adult
Biomarkers
Chemokine CCL2 genetics
Genotype
HIV Infections virology
Humans
Immunity, Innate physiology
Inflammation metabolism
Lymphocyte Activation
Male
Middle Aged
T-Lymphocytes physiology
Aging
Anti-HIV Agents therapeutic use
Bacterial Translocation physiology
Chemokine CCL2 metabolism
HIV Infections metabolism
HIV-1
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 213
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26494772
- Full Text :
- https://doi.org/10.1093/infdis/jiv501