1. Solution studies, synthesis and antibacterial activity of Ga(III) complexes with bis-kojate derivatives.
- Author
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O'Ferrall LM, Fantasia A, Chan K, Teixeira LM, Kavanagh K, O'Connor C, Santos MA, Chaves S, Nurchi VM, Crisponi G, Zoroddu MA, Griffith DM, and Cappai R
- Subjects
- Ligands, Gallium chemistry, Gallium pharmacology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Coordination Complexes pharmacology, Coordination Complexes chemical synthesis, Coordination Complexes chemistry, Microbial Sensitivity Tests
- Abstract
Given the recognized major problem of microbial drug resistance for human health, new metal-based drugs have been currently explored for their antimicrobial properties, including gallium-based compounds as potential metallophores that could perturb Fe's interactions with proteins. Herein we have designed and synthesized two bis-kojate ligands (named L4 and L6) and studied their Ga(III) complexes for their physico-chemical and biological properties. In particular a detailed study of their complexation properties in aqueous solution, showed equilibrium models with formation of quite stable dinuclear 2:3 metal:ligand complexes, though with different stability. Solid state complexes were also prepared and characterized and complementary DFT studies indicated that [Ga
2 (L4)3 ] complex, with higher stability, seems to adopt a three-ligand bridging conformation, while that for L6 adopt a one ligand bridging conformation. Preliminary investigation of the antibacterial activity of these gallium complexes showed antipseudomonal activity, which appeared higher for the complex with L4, a feature of potential interest for the scientific community., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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