Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil.

Authors :: Prazeres Magalhães P
De Magalhães Queiroz DM
Campos Barbosa DV
Aguiar Rocha G
Nogueira Mendes E
Santos A
Valle Corrêa PR
Camargos Rocha AM
Martins Teixeira L
Affonso de Oliveira C
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2002 Jun; Vol. 46 (6), pp. 2021-3.
Publication Year :: 2002
Abstract: Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.

Subjects :: Bacterial Proteins metabolism
Brazil epidemiology
DNA, Bacterial genetics
Drug Resistance, Microbial
Helicobacter Infections microbiology
Helicobacter pylori genetics
Humans
Point Mutation
Anti-Bacterial Agents therapeutic use
Antigens, Bacterial
Clarithromycin therapeutic use
Helicobacter Infections drug therapy
Helicobacter Infections epidemiology
Helicobacter pylori drug effects
Metronidazole therapeutic use

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