1. Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi.
- Author
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Ngoc NT, Hanh TTH, Quang TH, Cuong NX, Nam NH, Thao DT, Thung DC, Kiem PV, and Minh CV
- Subjects
- Animals, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Molecular Conformation, Stereoisomerism, Steroids chemistry, Steroids isolation & purification, Structure-Activity Relationship, Anthozoa chemistry, Antineoplastic Agents pharmacology, Steroids pharmacology
- Abstract
Fourteen polyhydroxylated steroids including six new compounds, ehrensteroids A - F (1-6), were isolated from the Vietnamese soft coral Sarcophyton ehrenbergi after applying various chromatographic separations. The structure elucidation was done by detailed analysis of 1D, 2D NMR and HR QTOF mass spectra. In addition, significant cytotoxicity (IC
50 values ranging from 8.45 ± 0.56 to 38.27 ± 2.39 μM) against all five tested cancer cell lines as LU-1 (lung cancer), HepG2 (hepatoma cancer), MCF-7 (breast cancer), HL-60 (acute leukemia), and SW480 (colon adenocarcinoma) was observed for compounds 1, 2, 6-10, and 12-14, whereas this activity on LU-1 (IC50 = 21.91 ± 2.72 μM) and HepG2 (IC50 = 20.32 ± 0.03 μM) cell lines was also observed for 4., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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