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Osteoclastogenesis Modulatory Steroids from the South China Sea Gorgonian Coral Iciligorgia sp.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2020 Jun; Vol. 17 (6), pp. e2000266. Date of Electronic Publication: 2020 May 28. - Publication Year :
- 2020
-
Abstract
- A new 9,11-secosteroid, (22R)-22-acetoxy-3β,6α,11-trihydroxy-9,11-seco-5α-cholest-7-en-9-one, along with twelve known analogues were isolated from the South China Sea gorgonian coral Iciligorgia sp. Their structures were determined by the spectroscopic analysis and comparison with reported data. In an in vitro test of osteoclastic differentiation, three compounds exhibited significant down-regulating effect whereas two compounds showed significant up-regulating effect at 0.5 and 1.0 μm. This is the first report of the chemical investigation of the gorgonian Iciligorgia sp. The acetoxy substitution at C-22 seems to play an important role in the regulating activity.<br /> (© 2020 Wiley-VHCA AG, Zurich, Switzerland.)
- Subjects :
- Animals
Anthozoa metabolism
Bone Marrow Cells cytology
Cell Differentiation drug effects
Cells, Cultured
Macrophages cytology
Macrophages metabolism
Magnetic Resonance Spectroscopy
Male
Mice
Mice, Inbred C57BL
Molecular Conformation
Osteogenesis drug effects
Spectrometry, Mass, Electrospray Ionization
Steroids isolation & purification
Steroids pharmacology
Anthozoa chemistry
Steroids chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 32463564
- Full Text :
- https://doi.org/10.1002/cbdv.202000266