1. Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation
- Author
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José Darias, Jose M. de la Rosa, Mercedes Cueto, Germán Perdomo, Luis D'Croz, Irene Cózar-Castellano, Amalia B. Gallardo, Ana R. Díaz-Marrero, European Commission, Ministerio de Economía y Competitividad (España), and Cabildo de Tenerife
- Subjects
Bridged-Ring Compounds ,Models, Molecular ,diketocembranolides ,Magnetic Resonance Spectroscopy ,cembranolides ,Pharmaceutical Science ,Leptogorgia ,010402 general chemistry ,01 natural sciences ,Article ,Cell Line ,Pancreatic beta cell proliferation ,Endocrinology ,Pancreatic beta Cells ,Insulin-Secreting Cells ,Drug Discovery ,Endocrinología ,Animals ,Rubifolide ,Beta (finance) ,Furans ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,lcsh:QH301-705.5 ,Cell Proliferation ,biology ,Molecular Structure ,010405 organic chemistry ,Chemistry ,pancreatic beta-cells ,chloro-furanocembranolides ,biology.organism_classification ,Anthozoa ,Molecular biology ,0104 chemical sciences ,3. Good health ,Rats ,Scabrolide D ,lcsh:Biology (General) ,furanocembranolides ,seco-furanocembranolides ,Oxidation-Reduction - Abstract
This article belongs to the Special Issue Progress on Marine Natural Products as Lead Compounds., Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells., This work was supported by the Ministerio de Ciencia e Innovación (SAF2009-0839 and RTA 2015-00010-C03-02). ARDM acknowledges funding from IMBRAIN project (FP7-REGPOT-2012-CT2012-31637-IMBRAIN) and from Cabildo de Tenerife (Agustín de Betancourt Programme). A.B.G. would like to thank Convenio Universidad de Magallanes (Chile) and CSIC, project 2009CL0031, for financial support.
- Published
- 2018