1. Osteoblast MR deficiency protects against adverse ventricular remodeling after myocardial infarction
- Author
-
Yong-Li, Wang, Lan, Bai, Xue-Rui, Shi, Hong, Zhu, Lin-Juan, Du, Yuan, Liu, Xiao-Xin, Ma, Wen-Zhen, Lin, Ting, Liu, Jian-Yong, Sun, Yan, Liu, Xu-Guang, Guo, Lu-Jun, Zhou, Bo-Yan, Chen, Shuai, Shao, Xiao-Qian, Meng, Yu-Lin, Li, Ruo-Gu, Li, and Sheng-Zhong, Duan
- Subjects
Heart Failure ,Mice ,Osteoblasts ,Ventricular Remodeling ,Myocardial Infarction ,Animals ,Humans ,Spironolactone ,Cardiology and Cardiovascular Medicine ,Molecular Biology ,Mineralocorticoid Receptor Antagonists - Abstract
Mineralocorticoid receptor (MR) antagonists have been clinically used to treat heart failure. However, the underlying cellular and molecular mechanisms remain incompletely understood.Using osteoblast MR knockout (MRMR deficiency in osteoblasts alleviates pathological ventricular remodeling after MI, likely through its regulation on OCN. Spironolactone may work through osteoblast MR/OCN axis to exert its therapeutic effects on pathological ventricular remodeling and heart failure in mice and human patients.
- Published
- 2022