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Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis
- Source :
- Clinical and Experimental Pharmacology & Physiology
- Publication Year :
- 2019
-
Abstract
- Myocardial injury caused by the myocardial ischaemia (MI) is still a troublesome condition in the clinic, including apoptosis, oxidative stress and inflammation. Diosmetin inhibits the cellular apoptosis and inflammatory response and enhances antioxidant activity. So, this study was designed to investigate the cardioprotective effects of diosmetin on MI model neonatal rats. Forty Sprague Dawley (SD) rats 7 days old were randomly divided into five groups. Four groups of rats received diosmetin (50, 100, and 200 mg/kg) or vehicle (MI group) after ischaemia. Another group received vehicle without ischaemia to serve as a control group. Rats were pretreated with diosmetin intraperitoneally for 7 days and intoxicated with isoproterenol (ISO, 85 mg/kg, sc) on the last 2 days. The expression of apoptotic molecules, myocardial systolic function index, antioxidant enzymes and myocardial enzyme was analyzed. Compared with the control group, the proliferation marker proteins of Ki67 were increased significantly (P
- Subjects :
- 0301 basic medicine
Male
Antioxidant
Physiology
medicine.medical_treatment
diosmetin
Ischemia
Myocardial Ischemia
Inflammation
Apoptosis
Pharmacology
Cardiovascular ‐ Cardiology
medicine.disease_cause
Contractility
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Physiology (medical)
medicine
Animals
Protein kinase B
Flavonoids
business.industry
Myocardium
medicine.disease
Diosmetin
myocardial ischaemia
Rats
Oxidative Stress
myocardial apoptosis
030104 developmental biology
chemistry
Animals, Newborn
030220 oncology & carcinogenesis
Original Article
medicine.symptom
ORIGINAL ARTICLES
business
Oxidative stress
Subjects
Details
- ISSN :
- 14401681
- Volume :
- 47
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental pharmacologyphysiology
- Accession number :
- edsair.doi.dedup.....f6ac006d2eb9d0d6b170630d898d5fea