1. Effect of Neuropeptide Y on Action Potential of Working Right Atrial Cardiomyocytes in Early Postnatal Ontogeny
- Author
-
N. G. Iskakov, Timur Lvovich Zefirov, T. A. Anikina, A. A. Zverev, and Andrey L. Zefirov
- Subjects
0301 basic medicine ,Aging ,medicine.medical_specialty ,Ontogeny ,Action Potentials ,Right atrial ,General Biochemistry, Genetics and Molecular Biology ,Membrane Potentials ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Repolarization ,Myocytes, Cardiac ,Neuropeptide Y ,Heart Atria ,Cells, Cultured ,Membrane potential ,Chemistry ,General Medicine ,Neuropeptide Y receptor ,Myocardial Contraction ,In vitro ,Rats ,Potassium current ,030104 developmental biology ,Endocrinology ,Animals, Newborn ,Postnatal ontogeny ,030217 neurology & neurosurgery - Abstract
The effects of neuropeptide Y (10—9-10—6 M) on electrical activity of right atrial cardiomyocytes of rats aging 7, 21, and 100 days were examined in vitro. Neuropeptide Y affected the amplitude-temporal parameters of the action potential in these cells. It decreased the duration of repolarization phase in 7-day-old rats in concentrations of 10—8 and 10—7 M, in 21-day-old rats at 10—8 and 10—6 M, and in 100-day-old at 10—6 M. The data indicate elevation of total membrane potassium current under the action of neuropeptide Y.
- Published
- 2019