1. Determination of various drugs in rodent diet mixtures.
- Author
-
Hucker HB and Stauffer SC
- Subjects
- Amitriptyline analogs & derivatives, Animals, Benzylidene Compounds analysis, Chromatography, Gas, Chromatography, Thin Layer, Dibenzocycloheptenes analysis, Drug Stability, Halofenate analysis, Indenes analysis, Methods, Rodentia, Spectrophotometry, Animal Feed analysis, Pharmaceutical Preparations analysis
- Abstract
Methods employing solvent extraction, thin-layer chromatography, gas-liquid chromatography, and UV spectrophotometry are described for the quantitative determination of halofenate, cyclobenzaprine and sulindac in rodent diet mixtures. Halofenate was hydrolyzed to its free acid derivative and converted to a methyl ester prior to assay. The drugs were shown to be stable when stored in food mixtures at room temperature for seven days. Diet mixtures containing the three drugs were demonstrated to be uniformly mixed by the procedure employed.
- Published
- 1977
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