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Determination of various drugs in rodent diet mixtures.
- Source :
-
Journal of chromatography [J Chromatogr] 1977 Jan 21; Vol. 131, pp. 357-63. - Publication Year :
- 1977
-
Abstract
- Methods employing solvent extraction, thin-layer chromatography, gas-liquid chromatography, and UV spectrophotometry are described for the quantitative determination of halofenate, cyclobenzaprine and sulindac in rodent diet mixtures. Halofenate was hydrolyzed to its free acid derivative and converted to a methyl ester prior to assay. The drugs were shown to be stable when stored in food mixtures at room temperature for seven days. Diet mixtures containing the three drugs were demonstrated to be uniformly mixed by the procedure employed.
- Subjects :
- Amitriptyline analogs & derivatives
Animals
Benzylidene Compounds analysis
Chromatography, Gas
Chromatography, Thin Layer
Dibenzocycloheptenes analysis
Drug Stability
Halofenate analysis
Indenes analysis
Methods
Rodentia
Spectrophotometry
Animal Feed analysis
Pharmaceutical Preparations analysis
Subjects
Details
- Language :
- English
- Volume :
- 131
- Database :
- MEDLINE
- Journal :
- Journal of chromatography
- Publication Type :
- Academic Journal
- Accession number :
- 558222
- Full Text :
- https://doi.org/10.1016/s0021-9673(00)80952-8