1. Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. A Randomized Controlled Trial
- Author
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Takashi Uzu, Shin-Ichi Araki, Atsunori Kashiwagi, Masakazu Haneda, Daisuke Koya, Hiroki Yokoyama, Yasuo Kida, Motoyoshi Ikebuchi, Takaaki Nakamura, Masataka Nishimura, Noriko Takahara, Toshiyuki Obata, Nobuyuki Omichi, Katsuhiko Sakamoto, Ryosuke Shingu, Hideki Taki, Yoshio Nagai, Hiroaki Tokuda, Munehiro Kitada, Miwa Misawa, Akira Nishiyama, Hiroyuki Kobori, Hiroshi Maegawa, and Shiga Committee for Preventing Diabetic Nephropathy
- Subjects
Angiotensin receptor ,Physiology ,Peptide Hormones ,030232 urology & nephrology ,Angiotensinogen ,lcsh:Medicine ,Blood Pressure ,Type 2 diabetes ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Biochemistry ,Vascular Medicine ,Renin-Angiotensin System ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Fumarates ,Chronic Kidney Disease ,Renin ,Medicine and Health Sciences ,Medicine ,Diabetic Nephropathies ,Prospective Studies ,lcsh:Science ,Multidisciplinary ,female genital diseases and pregnancy complications ,Type 2 Diabetes ,Treatment Outcome ,Nephrology ,Creatinine ,Hypertension ,medicine.symptom ,hormones, hormone substitutes, and hormone antagonists ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Urinary system ,Urology ,Excretion ,03 medical and health sciences ,Angiotensin Receptor Antagonists ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Albuminuria ,Humans ,cardiovascular diseases ,Antihypertensive Agents ,business.industry ,urogenital system ,lcsh:R ,Biology and Life Sciences ,Aliskiren ,medicine.disease ,Amides ,Hormones ,Blood pressure ,chemistry ,Diabetes Mellitus, Type 2 ,Metabolic Disorders ,Kidney Failure, Chronic ,lcsh:Q ,Microalbuminuria ,business ,Physiological Processes - Abstract
Background In patients with diabetes, albuminuria is a risk marker of end-stage renal disease and cardiovascular events. An increased renin-angiotensin system activity has been reported to play an important role in the pathological processes in these conditions. We compared the effect of aliskiren, a direct renin inhibitor (DRI), with that of angiotensin receptor blockers (ARBs) on albuminuria and urinary excretion of angiotensinogen, a marker of intrarenal renin-angiotensin system activity. Methods We randomly assigned 237 type 2 diabetic patients with high-normal albuminuria (10 to
- Published
- 2016