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Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. A Randomized Controlled Trial
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 12, p e0164936 (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, 2016.
-
Abstract
- Background In patients with diabetes, albuminuria is a risk marker of end-stage renal disease and cardiovascular events. An increased renin-angiotensin system activity has been reported to play an important role in the pathological processes in these conditions. We compared the effect of aliskiren, a direct renin inhibitor (DRI), with that of angiotensin receptor blockers (ARBs) on albuminuria and urinary excretion of angiotensinogen, a marker of intrarenal renin-angiotensin system activity. Methods We randomly assigned 237 type 2 diabetic patients with high-normal albuminuria (10 to
- Subjects :
- Angiotensin receptor
Physiology
Peptide Hormones
030232 urology & nephrology
Angiotensinogen
lcsh:Medicine
Blood Pressure
Type 2 diabetes
030204 cardiovascular system & hematology
urologic and male genital diseases
Biochemistry
Vascular Medicine
Renin-Angiotensin System
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Fumarates
Chronic Kidney Disease
Renin
Medicine and Health Sciences
Medicine
Diabetic Nephropathies
Prospective Studies
lcsh:Science
Multidisciplinary
female genital diseases and pregnancy complications
Type 2 Diabetes
Treatment Outcome
Nephrology
Creatinine
Hypertension
medicine.symptom
hormones, hormone substitutes, and hormone antagonists
Research Article
medicine.medical_specialty
Endocrine Disorders
Urinary system
Urology
Excretion
03 medical and health sciences
Angiotensin Receptor Antagonists
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Albuminuria
Humans
cardiovascular diseases
Antihypertensive Agents
business.industry
urogenital system
lcsh:R
Biology and Life Sciences
Aliskiren
medicine.disease
Amides
Hormones
Blood pressure
chemistry
Diabetes Mellitus, Type 2
Metabolic Disorders
Kidney Failure, Chronic
lcsh:Q
Microalbuminuria
business
Physiological Processes
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....cb1c1fab0a700bcccdbd025b2e4c5a11