1. Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model
- Author
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Ling-Ling Weng, Tao Chen, Jin-Bo Lin, Shang-Hui Yi, Hai-Liang Zhao, Hao-Tao Zeng, Li-Tao Yang, Minguang Zhang, Yi-Sheng Li, Sheng-ming Lin, Shu-Qi Qiu, Dong-Wei Xin, and Jian-Feng Xiang
- Subjects
Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Liver tumor ,Epidemiology ,Angiogenesis ,medicine.medical_treatment ,Blotting, Western ,Hepatic Artery ,Polysaccharides ,Tumor Cells, Cultured ,medicine ,Animals ,Humans ,Asparagus ,Hepatic artery embolization ,Carcinoma 256, Walker ,Chemoembolization, Therapeutic ,Rats, Wistar ,Transcatheter arterial chemoembolization ,Chemotherapy ,Neovascularization, Pathologic ,biology ,business.industry ,Liver Neoplasms ,Public Health, Environmental and Occupational Health ,food and beverages ,biology.organism_classification ,medicine.disease ,Xenograft Model Antitumor Assays ,Rats ,Survival Rate ,Oncology ,Hepatocellular carcinoma ,Cancer research ,Asparagus Plant ,business ,Liver cancer - Abstract
Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.
- Published
- 2015