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Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model
- Source :
- Asian Pacific Journal of Cancer Prevention. 15:10949-10955
- Publication Year :
- 2015
- Publisher :
- Asian Pacific Organization for Cancer Prevention, 2015.
-
Abstract
- Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Liver tumor
Epidemiology
Angiogenesis
medicine.medical_treatment
Blotting, Western
Hepatic Artery
Polysaccharides
Tumor Cells, Cultured
medicine
Animals
Humans
Asparagus
Hepatic artery embolization
Carcinoma 256, Walker
Chemoembolization, Therapeutic
Rats, Wistar
Transcatheter arterial chemoembolization
Chemotherapy
Neovascularization, Pathologic
biology
business.industry
Liver Neoplasms
Public Health, Environmental and Occupational Health
food and beverages
biology.organism_classification
medicine.disease
Xenograft Model Antitumor Assays
Rats
Survival Rate
Oncology
Hepatocellular carcinoma
Cancer research
Asparagus Plant
business
Liver cancer
Subjects
Details
- ISSN :
- 15137368
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Cancer Prevention
- Accession number :
- edsair.doi.dedup.....5c199fe978164da3252f53d320572d61