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This study aimed to investigate the effects of a single bolus and continuous rate infusion (CRI) of 1% propofol on cholesterol and triglyceride levels of healthy bitches undergoing elective ovariohysterectomy. 10 healthy bitches undergoing elective ovariohysterectomy had blood samples obtained at baseline (T B ), 15 minutes following premedication with acepromazine and morphine (T PM ), after an intravenous bolus of propofol (induction to anesthesia, T IND ) and following 90 minutes of CRI of propofol started at 0.4 mg kg -1 min -1 and adjusted according to individual requirements (T CRI ). Data were initially tested for normality using the Shapiro-Wilk test, and comparisons were performed using Friedman followed by Dunn post-hoc test. Serum cholesterol levels significantly decreased at T IND and T CRI (median [min-max] 201 mg dL -1 [111-234 mg dL -1 ], and 215 mg dL -1 [111-239 mg dL -1 ]), respectively, compared with T B (232 [128-245 mg dL -1 ]) and T PM (206 [115-255 mg dL -1 ]). No differences were found between T IND and T CRI . Triglyceride levels increased significantly at T IND (120 [67-231 mg dL -1 ]) and T CRI (229 [73-549 mg dL -1 ]) compared with T PM (36 [51-29 mg dL -1 ]), and T CRI compared with T B . In conclusion, 1% propofol lipid emulsion significantly increases serum triglycerides and causes lipemia in healthy dogs at a single bolus or CRI., (Copyright © 2021 Elsevier Inc. All rights reserved.)