Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy.

This study aimed to investigate the effects of a single bolus and continuous rate infusion (CRI) of 1% propofol on cholesterol and triglyceride levels of healthy bitches undergoing elective ovariohysterectomy. 10 healthy bitches undergoing elective ovariohysterectomy had blood samples obtained at baseline (T _B ), 15 minutes following premedication with acepromazine and morphine (T _PM ), after an intravenous bolus of propofol (induction to anesthesia, T _IND ) and following 90 minutes of CRI of propofol started at 0.4 mg kg ^-1 min ^-1 and adjusted according to individual requirements (T _CRI ). Data were initially tested for normality using the Shapiro-Wilk test, and comparisons were performed using Friedman followed by Dunn post-hoc test. Serum cholesterol levels significantly decreased at T _IND and T _CRI (median [min-max] 201 mg dL ^-1 [111-234 mg dL ^-1 ], and 215 mg dL ^-1 [111-239 mg dL ^-1 ]), respectively, compared with T _B (232 [128-245 mg dL ^-1 ]) and T _PM (206 [115-255 mg dL ^-1 ]). No differences were found between T _IND and T _CRI . Triglyceride levels increased significantly at T _IND (120 [67-231 mg dL ^-1 ]) and T _CRI (229 [73-549 mg dL ^-1 ]) compared with T _PM (36 [51-29 mg dL ^-1 ]), and T _CRI compared with T _B . In conclusion, 1% propofol lipid emulsion significantly increases serum triglycerides and causes lipemia in healthy dogs at a single bolus or CRI.
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