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Your search keyword '"Fumiko Fujisaki"' showing total 9 results
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9 results on '"Fumiko Fujisaki"'

1. Synthesis and Antibacterial Evaluation of Some New 5-Substituted Hydantoins and Novel Twin-Drug Type Derivatives

Author

Maki Nakamura, Miki Ito, Saho Goto, Nobuhiro Kashige, Kunihiro Sumoto, Makoto Furutachi, Ayumi Ejima, Fumiko Fujisaki, Reika Tsuru, Hatsumi Aki, Toshiaki Gondo, and Fumio Miake

Subjects
Pharmacology, Drug, 010405 organic chemistry, Chemistry, media_common.quotation_subject, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Analytical Chemistry, media_common
Published
2016
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7. A Synthetic Application of β-Aminoalanines to Some New 5-Dialkylaminomethyl-3-phenylhydantoin Derivatives

Author

Fumiko Fujisaki, Kaori Shoji, and Kunihiro Sumoto

Subjects
Pharmacology, Addition reaction, Organic Chemistry, Deamination, Hydantoin, Medicinal chemistry, Pyrrolidine, Analytical Chemistry, chemistry.chemical_compound, chemistry, Derivative (finance), Hydantoin derivatives, Piperidine, Phenyl isocyanate
Abstract

5-Dialkylaminomethylhydantoins (3) were synthesized from β-aminoalanines (1) as the starting materials in two stages. Intermediate urea derivatives (2) prepared from the addition reaction of β-aminoalanines to phenyl isocyanate are easily cyclized to 5-dialkylaminomethylhydantoins (3) with good yields. The deamination reaction of some of the hydantoin derivatives (3a, 3b) in water were observed and resulted in the formation of 3-phenyl-5-methylenehydantoin (4). The hydantoin derivative (3b) regenerated a urea derivative (2c, d) by treatment with excess amounts of pyrrolidine or piperidine.

Published
2009
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8. A New Route for the Synthesis of Linezolid Mimetic 3,4-Disubstituted Oxazolidin-2-one Derivatives

Author

Nobuhiro Abe, Kunihiro Sumoto, and Fumiko Fujisaki

Subjects
Pharmacology, Phthalimide, chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Carboxylic acid, Organic Chemistry, Linezolid, Diethyl carbonate, Organic chemistry, Ester hydrochloride, Analytical Chemistry, Antibacterial agent
Abstract

New oxazolidin-2-ones (3), which mimic the clinically useful antibacterial agent (1) (Linezolid) were prepared by using a cyclization procedure with diethyl carbonate from aminoalcohol (7) starting with DL-serine methyl ester hydrochloride (4) and aromatic carboxylic acid derivatives (5).

Published
2008
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9. 3-Phenylhexahydro-1(3H)-isobenzofuranones

Author

Kunihiro Sumoto, Seiji Miyano, Fumiko Fujisaki, and Nobuhiro Abe

Subjects
Pharmacology, chemistry.chemical_classification, Bicyclic molecule, Chemistry, Stereochemistry, Organic Chemistry, Nuclear magnetic resonance spectroscopy, Lactone, Analytical Chemistry
Published
1987
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