A New Route for the Synthesis of Linezolid Mimetic 3,4-Disubstituted Oxazolidin-2-one Derivatives

Authors :: Nobuhiro Abe
Kunihiro Sumoto
Fumiko Fujisaki
Source :: HETEROCYCLES. 75:1681
Publication Year :: 2008
Publisher :: The Japan Institute of Heterocyclic Chemistry, 2008.
Abstract: New oxazolidin-2-ones (3), which mimic the clinically useful antibacterial agent (1) (Linezolid) were prepared by using a cyclization procedure with diethyl carbonate from aminoalcohol (7) starting with DL-serine methyl ester hydrochloride (4) and aromatic carboxylic acid derivatives (5).

Subjects :: Pharmacology
Phthalimide
chemistry.chemical_classification
chemistry.chemical_compound
chemistry
Carboxylic acid
Organic Chemistry
Linezolid
Diethyl carbonate
Organic chemistry
Ester hydrochloride
Analytical Chemistry
Antibacterial agent

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