1. Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase
- Author
-
Graziella Scandurra, Gino Giusi, Michelangelo Scopelliti, Viviana Figa, G. Cannata, Bruno Pignataro, Luigi Occhipinti, Giovanni Maira, Carmine Ciofi, Vincenzo Vinciguerra, Yana Aleeva, Occhipinti, Luigi [0000-0002-9067-2534], Apollo - University of Cambridge Repository, Aleeva, Yana, Maira, Giovanni, Scopelliti, Michelangelo, Vinciguerra, Vincenzo, Scandurra, Graziella, Cannata, Gianluca, Giusi, Gino, Ciofi, Carmine, Figa, Viviana, Occhipinti, Luigi G., and Pignataro, Bruno
- Subjects
polymer films ,Working electrode ,Monitoring ,Electrode ,Amperometric sensors ,biosensors ,chemical and biological sensors ,conductive films ,remote sensing ,thick film biosensors ,Instrumentation ,Electrical and Electronic Engineering ,02 engineering and technology ,Substrate (electronics) ,01 natural sciences ,Chemical and biological sensor ,PEDOT:PSS ,Glucose oxidase ,Sensitivity (control systems) ,Sugar ,Amperometric sensor ,biology ,Sensor system ,business.industry ,Thick film biosensor ,010401 analytical chemistry ,Conductive film ,021001 nanoscience & nanotechnology ,Amperometry ,0104 chemical sciences ,biology.protein ,Optoelectronics ,Gold ,Polymer film ,0210 nano-technology ,business ,Biosensor - Abstract
Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 $\mu \text{A}/({\mathrm {mM}} \cdot {\mathrm {cm}}^{2})$ are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).
- Published
- 2018