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Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase
- Publication Year :
- 2018
-
Abstract
- Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 $\mu \text{A}/({\mathrm {mM}} \cdot {\mathrm {cm}}^{2})$ are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).
- Subjects :
- polymer films
Working electrode
Monitoring
Electrode
Amperometric sensors
biosensors
chemical and biological sensors
conductive films
remote sensing
thick film biosensors
Instrumentation
Electrical and Electronic Engineering
02 engineering and technology
Substrate (electronics)
01 natural sciences
Chemical and biological sensor
PEDOT:PSS
Glucose oxidase
Sensitivity (control systems)
Sugar
Amperometric sensor
biology
Sensor system
business.industry
Thick film biosensor
010401 analytical chemistry
Conductive film
021001 nanoscience & nanotechnology
Amperometry
0104 chemical sciences
biology.protein
Optoelectronics
Gold
Polymer film
0210 nano-technology
business
Biosensor
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a8eca58d83e23999ce2a1c5cc86a6cda