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1. GAP Peptide Synthesis through the Design of a GAP Protecting Group: An Fmoc/ tBu Synthesis of Thymopentin Free from Polymers, Chromatography and Recrystallization.

Author

Seifert, Cole W., Paniagua, Armando, White, Gabrielle A., Cai, Lucy, and Li, Guigen

Subjects
*PEPTIDE synthesis, *CHEMICAL purification, *IMMUNOLOGICAL adjuvants, *POLYMER-supported catalysts, *CHROMATOGRAPHIC analysis, *RECRYSTALLIZATION (Chemistry)
Abstract

A novel method for Fmoc/ tBu solution-phase peptide synthesis and the development of a new benzyl-type group-assisted purification (GAP) protecting group is reported. This GAP protecting group is utilized in place of a polymer support, facilitating Cā†’N Fmoc peptide synthesis without chromatography or recrystallization. The GAP group can be added and removed in high yield, and was used to synthesize over 1 gram of the immunostimulant, thymopentin, in high overall yield (83 %) and purity (99 %). [ABSTRACT FROM AUTHOR]

Published
2016
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