Back to Search
Start Over
GAP Peptide Synthesis through the Design of a GAP Protecting Group: An Fmoc/ tBu Synthesis of Thymopentin Free from Polymers, Chromatography and Recrystallization.
- Source :
-
European Journal of Organic Chemistry . Mar2016, Vol. 2016 Issue 9, p1714-1719. 6p. - Publication Year :
- 2016
-
Abstract
- A novel method for Fmoc/ tBu solution-phase peptide synthesis and the development of a new benzyl-type group-assisted purification (GAP) protecting group is reported. This GAP protecting group is utilized in place of a polymer support, facilitating C→N Fmoc peptide synthesis without chromatography or recrystallization. The GAP group can be added and removed in high yield, and was used to synthesize over 1 gram of the immunostimulant, thymopentin, in high overall yield (83 %) and purity (99 %). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2016
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 113928414
- Full Text :
- https://doi.org/10.1002/ejoc.201600026