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1. In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species.

Author

Müller-Jakic B, Breu W, Pröbstle A, Redl K, Greger H, and Bauer R

Subjects
Animals, Cyclooxygenase Inhibitors isolation & purification, Sheep, Swine, Amides pharmacology, Cyclooxygenase Inhibitors pharmacology, Lipoxygenase Inhibitors, Plants, Medicinal chemistry
Abstract

Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.

Published
1994
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