In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species.

Authors :: Müller-Jakic B
Breu W
Pröbstle A
Redl K
Greger H
Bauer R
Source :: Planta medica [Planta Med] 1994 Feb; Vol. 60 (1), pp. 37-40.
Publication Year :: 1994
Abstract: Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.

Subjects :: Animals
Cyclooxygenase Inhibitors isolation & purification
Sheep
Swine
Amides pharmacology
Cyclooxygenase Inhibitors pharmacology
Lipoxygenase Inhibitors
Plants, Medicinal chemistry

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