1. A new morphinandienone alkaloid from the stems of Fissistigma tungfangense.
- Author
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Zhou Q, Fu YH, Zhang YQ, Wu SY, Song XP, Xu W, and Chen GY
- Subjects
- Alkaloids chemistry, Antirheumatic Agents isolation & purification, Cell Proliferation drug effects, Morphinans chemistry, Plant Stems chemistry, Synoviocytes drug effects, Alkaloids isolation & purification, Annonaceae chemistry, Morphinans isolation & purification
- Abstract
A new morphinandienone alkaloid, fissistigmine A (1), together with three known alkaloids (2-4), were isolated and identified from the stems of Fissistigma tungfangense. Among them, fissistigmine A (1) represents the first example of a novel naturally occurring morphinandienone alkaloid with a unique cleavage of the C-9-N-17 bond. All isolated compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proliferative effects on synoviocytes in vitro. Compound 1 exhibited inhibitory effect on the proliferation of synoviocytes with an IC
50 value of 114.6 ± 2.2 μM.- Published
- 2019
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