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A new morphinandienone alkaloid from the stems of Fissistigma tungfangense.
- Source :
-
Natural product research [Nat Prod Res] 2019 Feb; Vol. 33 (3), pp. 374-379. Date of Electronic Publication: 2018 Apr 09. - Publication Year :
- 2019
-
Abstract
- A new morphinandienone alkaloid, fissistigmine A (1), together with three known alkaloids (2-4), were isolated and identified from the stems of Fissistigma tungfangense. Among them, fissistigmine A (1) represents the first example of a novel naturally occurring morphinandienone alkaloid with a unique cleavage of the C-9-N-17 bond. All isolated compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proliferative effects on synoviocytes in vitro. Compound 1 exhibited inhibitory effect on the proliferation of synoviocytes with an IC <subscript>50</subscript> value of 114.6 ± 2.2 μM.
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 29630409
- Full Text :
- https://doi.org/10.1080/14786419.2018.1452011