1. Toxicity Management: Development of a novel and immune-mediated adverse events algorithm.
- Author
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Mistry, Haleigh E., Forbes, Sheryl G., and Fowler, Nathan
- Subjects
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HODGKIN'S disease treatment , *LYMPHOMA treatment , *ADRENOCORTICAL hormones , *ALGORITHMS , *CANCER patient medical care , *CANCER treatment , *COMBINATION drug therapy , *DRUG toxicity , *HEALTH care teams , *IMMUNOTHERAPY , *CASE studies , *EVIDENCE-based medicine , *PROFESSIONAL practice , *SPECIALTY hospitals - Abstract
BACKGROUND: Novel immunotherapy and biologic agents are being developed with the potential to improve outcomes and reduce long-term toxicities among individuals with hematologic malignancies. These emerging drugs affect neoplastic cells and the surrounding microenvironment, causing unique immune-mediated toxicities. OBJECTIVES: The aim was to develop an algorithm for clinical staff to manage unique toxicities associated with next-generation immunotherapies indicated in the hematologic population, using a system-focused approach. METHODS: Data were collected using specific toxicities based on the four major novel biologic classes. Immune-mediated adverse events were reported across studies. Based on published literature, institutional experience, and group consensus, a novel algorithm for managing immune-mediated toxicities was created. FINDINGS: The development of this treatment algorithm provides a more streamlined approach for managing common but unique toxicities and improves safety, compliance, patient outcome, and quality of life with novel immuno-oncologic agents. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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