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Toxicity Management: Development of a novel and immune-mediated adverse events algorithm.
- Source :
-
Clinical Journal of Oncology Nursing . 2017 Supplement, Vol. 21, p53-59. 7p. 2 Diagrams, 1 Chart. - Publication Year :
- 2017
-
Abstract
- BACKGROUND: Novel immunotherapy and biologic agents are being developed with the potential to improve outcomes and reduce long-term toxicities among individuals with hematologic malignancies. These emerging drugs affect neoplastic cells and the surrounding microenvironment, causing unique immune-mediated toxicities. OBJECTIVES: The aim was to develop an algorithm for clinical staff to manage unique toxicities associated with next-generation immunotherapies indicated in the hematologic population, using a system-focused approach. METHODS: Data were collected using specific toxicities based on the four major novel biologic classes. Immune-mediated adverse events were reported across studies. Based on published literature, institutional experience, and group consensus, a novel algorithm for managing immune-mediated toxicities was created. FINDINGS: The development of this treatment algorithm provides a more streamlined approach for managing common but unique toxicities and improves safety, compliance, patient outcome, and quality of life with novel immuno-oncologic agents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10921095
- Volume :
- 21
- Database :
- Academic Search Index
- Journal :
- Clinical Journal of Oncology Nursing
- Publication Type :
- Academic Journal
- Accession number :
- 123462987
- Full Text :
- https://doi.org/10.1188/17.CJON.S2.53-59