1. Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era
- Author
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Djaouida Bengoufa, L. Iordache, Alfred Mahr, Agathe Rami, Nesrine Day, Caroline Lascoux-Combe, Pierre-Olivier Sellier, Maguy Parrinello, Olivier Taulera, and Jean-Michel Molina
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,HAART ,Anti-nuclear antibody ,autoantibodies ,Observational Study ,HIV Infections ,antinuclear antibodies ,Gastroenterology ,Immunoglobulin G ,03 medical and health sciences ,Antigen ,Proteinase 3 ,immune system diseases ,Internal medicine ,Antiretroviral Therapy, Highly Active ,medicine ,Humans ,Anti-neutrophil cytoplasmic antibody ,biology ,business.industry ,Hypergammaglobulinemia ,Autoantibody ,HIV ,General Medicine ,Middle Aged ,medicine.disease ,3. Good health ,030104 developmental biology ,Cross-Sectional Studies ,biology.protein ,ANCAs ,Female ,Antibody ,business ,hypergammaglobulinemia ,Research Article - Abstract
Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze the association of their presence with hypergammaglobulinemia and immunovirological status. Blood samples from HIV1-infected patients without major concomitant illnesses followed in 2 hospitals in Paris, France were tested for immunovirological status, serum immunoglobulin G (IgG) level, antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), anti-extractable nuclear antigens (anti-ENAs), anticardiolipin (aCL), anti-β2glycoprotein1 (anti-β2GP1), and antineutrophil cytoplasmic antibodies (ANCAs). Clinically relevant AAbs were defined as ANAs with titers ≥1:160, anti-dsDNA or anti-ENA antibodies; aCL or anti-β2GP1 antibodies with a level ≥40 U/ml; and ANCAs reacting with proteinase 3 or myeloperoxidase. We included 92 patients (mean age 47 years, men 55%, sub-Saharan African background 55%, HAART 85%, mean CD4 lymphocyte count 611/mm3, viral load
- Published
- 2017