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Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era
Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era
- Source :
- Medicine
- Publication Year :
- 2017
- Publisher :
- Wolters Kluwer Health, 2017.
-
Abstract
- Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze the association of their presence with hypergammaglobulinemia and immunovirological status. Blood samples from HIV1-infected patients without major concomitant illnesses followed in 2 hospitals in Paris, France were tested for immunovirological status, serum immunoglobulin G (IgG) level, antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), anti-extractable nuclear antigens (anti-ENAs), anticardiolipin (aCL), anti-β2glycoprotein1 (anti-β2GP1), and antineutrophil cytoplasmic antibodies (ANCAs). Clinically relevant AAbs were defined as ANAs with titers ≥1:160, anti-dsDNA or anti-ENA antibodies; aCL or anti-β2GP1 antibodies with a level ≥40 U/ml; and ANCAs reacting with proteinase 3 or myeloperoxidase. We included 92 patients (mean age 47 years, men 55%, sub-Saharan African background 55%, HAART 85%, mean CD4 lymphocyte count 611/mm3, viral load
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
HAART
Anti-nuclear antibody
autoantibodies
Observational Study
HIV Infections
antinuclear antibodies
Gastroenterology
Immunoglobulin G
03 medical and health sciences
Antigen
Proteinase 3
immune system diseases
Internal medicine
Antiretroviral Therapy, Highly Active
medicine
Humans
Anti-neutrophil cytoplasmic antibody
biology
business.industry
Hypergammaglobulinemia
Autoantibody
HIV
General Medicine
Middle Aged
medicine.disease
3. Good health
030104 developmental biology
Cross-Sectional Studies
biology.protein
ANCAs
Female
Antibody
business
hypergammaglobulinemia
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 96
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....4750eaaec462c6d6f815c71255aa2b5d