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Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era

Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era

Authors :
Djaouida Bengoufa
L. Iordache
Alfred Mahr
Agathe Rami
Nesrine Day
Caroline Lascoux-Combe
Pierre-Olivier Sellier
Maguy Parrinello
Olivier Taulera
Jean-Michel Molina
Source :
Medicine
Publication Year :
2017
Publisher :
Wolters Kluwer Health, 2017.

Abstract

Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze the association of their presence with hypergammaglobulinemia and immunovirological status. Blood samples from HIV1-infected patients without major concomitant illnesses followed in 2 hospitals in Paris, France were tested for immunovirological status, serum immunoglobulin G (IgG) level, antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), anti-extractable nuclear antigens (anti-ENAs), anticardiolipin (aCL), anti-β2glycoprotein1 (anti-β2GP1), and antineutrophil cytoplasmic antibodies (ANCAs). Clinically relevant AAbs were defined as ANAs with titers ≥1:160, anti-dsDNA or anti-ENA antibodies; aCL or anti-β2GP1 antibodies with a level ≥40 U/ml; and ANCAs reacting with proteinase 3 or myeloperoxidase. We included 92 patients (mean age 47 years, men 55%, sub-Saharan African background 55%, HAART 85%, mean CD4 lymphocyte count 611/mm3, viral load

Details

Language :
English
ISSN :
15365964 and 00257974
Volume :
96
Issue :
10
Database :
OpenAIRE
Journal :
Medicine
Accession number :
edsair.doi.dedup.....4750eaaec462c6d6f815c71255aa2b5d