1. Prenatal Treatment with Dexamethasone in Suspected Congenital Adrenal Hyperplasia and Orofacial Cleft: a Case Report and Review of the Literature.
- Author
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Rijk Y, van Alfen-van der Velden J, and Claahsen-van der Grinten HL
- Subjects
- Adrenal Hyperplasia, Congenital complications, Adrenal Hyperplasia, Congenital diagnosis, Cleft Lip complications, Cleft Lip diagnosis, Cleft Palate complications, Cleft Palate diagnosis, Female, Humans, Pregnancy, Prenatal Diagnosis, Virilism complications, Virilism diagnosis, Adrenal Hyperplasia, Congenital drug therapy, Cleft Lip drug therapy, Cleft Palate drug therapy, Dexamethasone therapeutic use, Prenatal Care methods, Virilism drug therapy
- Abstract
Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is a genetic disorder that leads to hypocortisolism, hyperandrogenism and, in the most severe forms, also to hypoaldosteronism. Girls with classic CAH are born with virilized external genitalia. Prenatal dexamethasone (DXM) treatment can reduce virilization but may have side effects for mother and fetus. We present the first case of a girl who was born with CAH and an orofacial cleft. She was treated with prenatal DXM to prevent virilization. Oral clefts have to be considered as a potential side effect of prenatal DXM treatment., (Copyright© of YS Medical Media ltd.)
- Published
- 2017
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