Prenatal Treatment with Dexamethasone in Suspected Congenital Adrenal Hyperplasia and Orofacial Cleft: a Case Report and Review of the Literature.

Authors :: Rijk Y
van Alfen-van der Velden J
Claahsen-van der Grinten HL
Source :: Pediatric endocrinology reviews : PER [Pediatr Endocrinol Rev] 2017 Sep; Vol. 15 (1), pp. 21-25.
Publication Year :: 2017
Abstract: Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is a genetic disorder that leads to hypocortisolism, hyperandrogenism and, in the most severe forms, also to hypoaldosteronism. Girls with classic CAH are born with virilized external genitalia. Prenatal dexamethasone (DXM) treatment can reduce virilization but may have side effects for mother and fetus. We present the first case of a girl who was born with CAH and an orofacial cleft. She was treated with prenatal DXM to prevent virilization. Oral clefts have to be considered as a potential side effect of prenatal DXM treatment.<br /> (Copyright© of YS Medical Media ltd.)

Subjects :: Adrenal Hyperplasia, Congenital complications
Adrenal Hyperplasia, Congenital diagnosis
Cleft Lip complications
Cleft Lip diagnosis
Cleft Palate complications
Cleft Palate diagnosis
Female
Humans
Pregnancy
Prenatal Diagnosis
Virilism complications
Virilism diagnosis
Adrenal Hyperplasia, Congenital drug therapy
Cleft Lip drug therapy
Cleft Palate drug therapy
Dexamethasone therapeutic use
Prenatal Care methods
Virilism drug therapy

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