1. Relative vaccine effectiveness of MF59-adjuvanted vs high-dose trivalent inactivated influenza vaccines for prevention of test-confirmed influenza hospitalizations during the 2017-2020 influenza seasons.
- Author
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McGovern I, Chastek B, Bancroft T, Webb N, Imran M, Pelton SI, and Haag MDM
- Subjects
- Humans, Aged, Male, Female, Retrospective Studies, United States epidemiology, Aged, 80 and over, Vaccines, Inactivated administration & dosage, Vaccines, Inactivated immunology, Vaccination, Influenza Vaccines immunology, Influenza Vaccines administration & dosage, Influenza, Human prevention & control, Influenza, Human diagnosis, Influenza, Human epidemiology, Hospitalization statistics & numerical data, Polysorbates administration & dosage, Squalene administration & dosage, Adjuvants, Immunologic administration & dosage, Vaccine Efficacy, Seasons
- Abstract
Objectives: This study evaluated relative vaccine effectiveness (rVE) of MF59-adjuvanted trivalent inactivated influenza vaccine (aTIV) vs high-dose trivalent inactivated influenza vaccine (HD-TIV) for prevention of test-confirmed influenza emergency department visits and/or inpatient admissions ("ED/IP") and for IP admissions alone pooled across the 2017-2020 influenza seasons. Exploratory individual season analyses were also performed., Methods: This retrospective test-negative design study included United States (US) adults age ≥65 years vaccinated with aTIV or HD-TIV who presented to an ED or IP setting with acute respiratory or febrile illness during the 2017-2020 influenza seasons. Test-positive cases and test-negative controls were grouped by vaccine received. The rVE of aTIV vs HD-TIV was evaluated using a combination of inverse probability of treatment weighting and logistic regression to adjust for potential confounders., Results: Pooled analyses over the three seasons found no significant differences in the rVE of aTIV vs HD-TIV for prevention of test-confirmed influenza ED/IP (-2.5% [-19.6, 12.2]) visits and admissions or IP admissions alone (-1.6% [-22.5, 15.7]). The exploratory individual season analyses also showed no significant differences., Conclusions: Evidence from the 2017-2020 influenza seasons indicates aTIV and HD-TIV are comparable for prevention of test-confirmed influenza ED/IP visits in US adults age ≥65 years., Competing Interests: Declarations of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: IM, MI, and MH are an employee of CSL Seqirus. IM and MH hold stock in CSL Limited. BC, TB, NW are employees of Optum, which received funding from CSL Seqirus in support of this work. SP received financial support from CSL Seqirus in support of this work., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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