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Your search keyword '"Nigmatullina LR"' showing total 2 results
Start Over Author "Nigmatullina LR" Topic adjuvants, immunologic
2 results on '"Nigmatullina LR"'

1. [Study of pharmacological properties of betulin bishemiphthalate].

Author

Karachurina LT, Sapozhnikova TA, Zarudiĭ FS, Flekhter OB, Nigmatullina LR, and Galin FZ

Subjects
Acute Disease, Adjuvants, Immunologic toxicity, Animals, Antibody Formation drug effects, Antioxidants toxicity, Chemical and Drug Induced Liver Injury prevention & control, Immunity, Cellular drug effects, Lethal Dose 50, Lipid Peroxidation drug effects, Liver enzymology, Mice, Phthalic Acids toxicity, Radiation Injuries mortality, Radiation Injuries prevention & control, Radiation-Protective Agents toxicity, Toxicity Tests, Acute, Triterpenes toxicity, Adjuvants, Immunologic pharmacology, Antioxidants pharmacology, Liver drug effects, Phthalic Acids pharmacology, Radiation-Protective Agents pharmacology, Triterpenes pharmacology
Abstract

The results of pharmacological tests showed that betulin bishemiphthalate possesses hepatoprotector, antioxidant, and immunotropic properties. Administered in combination with hydroxymethyluracil, that betulin bishemiphthalate prevented the loss of experimental animals upon irradiation.

Published
2003

2. [Synthesis and pharmacological activity of betulin dinicotinate].

Author

Flekhter OB, Karachurina LT, Nigmatullina LR, Sapozhnikova TA, Baltina LA, Zarudiĭ FS, Galin FZ, Spirikhin LV, Tolstikov GA, and Pliasunova OA

Subjects
Adjuvants, Immunologic therapeutic use, Adjuvants, Immunologic toxicity, Animals, Anti-HIV Agents therapeutic use, Anti-HIV Agents toxicity, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Anti-Inflammatory Agents, Non-Steroidal toxicity, Antibody Formation drug effects, Arthritis drug therapy, Betula chemistry, Burns drug therapy, Cell Line, Cell Survival drug effects, Disease Models, Animal, Dose-Response Relationship, Drug, HIV Core Protein p24 analysis, HIV-1 drug effects, Humans, Lethal Dose 50, Mice, Plant Bark chemistry, Rats, Stomach Ulcer drug therapy, Triterpenes chemistry, Triterpenes isolation & purification, Triterpenes therapeutic use, Triterpenes toxicity, Adjuvants, Immunologic chemical synthesis, Anti-HIV Agents chemical synthesis, Anti-Inflammatory Agents, Non-Steroidal chemical synthesis, Triterpenes chemical synthesis
Abstract

The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3,28-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, untiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru.

Published
2002
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