1. Role of BMP7 in appetite regulation, adipogenesis, and energy expenditure.
- Author
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Saini S, Duraisamy AJ, Bayen S, Vats P, and Singh SB
- Subjects
- Humans, Adipogenesis physiology, Appetite Regulation physiology, Bone Morphogenetic Protein 7 physiology, Energy Metabolism physiology, Signal Transduction physiology
- Abstract
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions. This review will also discuss the synthesis and action of BMP7, along with its receptors and signal transduction. A brief note about BMP7-mediated brown fat development and energy balance is also discussed.
- Published
- 2015
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