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Role of BMP7 in appetite regulation, adipogenesis, and energy expenditure.
- Source :
-
Endocrine [Endocrine] 2015 Mar; Vol. 48 (2), pp. 405-9. Date of Electronic Publication: 2014 Sep 02. - Publication Year :
- 2015
-
Abstract
- Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions. This review will also discuss the synthesis and action of BMP7, along with its receptors and signal transduction. A brief note about BMP7-mediated brown fat development and energy balance is also discussed.
Details
- Language :
- English
- ISSN :
- 1559-0100
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Endocrine
- Publication Type :
- Academic Journal
- Accession number :
- 25178649
- Full Text :
- https://doi.org/10.1007/s12020-014-0406-8