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Start Over Author "Zhang, Xueya" Topic acute promyelocytic leukemia
2 results on '"Zhang, Xueya"'

2. Resistance to arsenic trioxide and retinoic acid therapy in acute promyelocytic leukemia.

Author

Zhang, Xueya and Pan, Jingxin

Subjects
*ACUTE promyelocytic leukemia, *TRETINOIN, *ARSENIC trioxide, *GENETIC mutation, *LEUKEMIA, *PATIENTS, *PROGNOSIS, *GENE therapy
Abstract

The article presents a case study of a patient with low-risk acute promyelocytic leukemia (APL) presented with first relapse after conventional treatments using two drugs all-trans retinoic acid (ATRA) and arsenic trioxide (ATO).Topics discussed include distinctly uncommon clinical course associated with a mutation in the promyelocytic leukemia gene (PML) allele, effect on the hybrid PML-RARA allele from mutations and poor prognosis of ATO-resistant APL patients.

Published
2017
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