1. Long non-coding RNA RP11-552M11.4 favors tumorigenesis and development of cervical cancer via modulating miR-3941/ATF1 signaling
- Author
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Liang Zhao, Yunsheng Xu, Xuan Liu, Rongying Ou, Yi Ren, Jianrong Li, Wenfeng Li, Wangying Zhou, Jiangmin Lv, Cheng Zhang, and Xiangyun Li
- Subjects
Carcinogenesis ,Uterine Cervical Neoplasms ,02 engineering and technology ,Biology ,medicine.disease_cause ,Biochemistry ,law.invention ,03 medical and health sciences ,Structural Biology ,law ,Cell Line, Tumor ,medicine ,Humans ,Molecular Biology ,030304 developmental biology ,Cell Proliferation ,0303 health sciences ,ATF1 ,Base Sequence ,Competing endogenous RNA ,Cell growth ,RNA ,Proteins ,General Medicine ,Middle Aged ,021001 nanoscience & nanotechnology ,medicine.disease ,eye diseases ,Long non-coding RNA ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,Cancer research ,Disease Progression ,Suppressor ,Female ,RNA, Long Noncoding ,0210 nano-technology ,Ovarian cancer ,Signal Transduction - Abstract
As one of the most aggressive malignancies, cervical cancer (CC) which mainly affects females has high risks of relapse and death. Long non-coding RNA (lncRNA) RP11-552M11.4 is verified to promote the progression of ovarian cancer; nevertheless, its role and the probable molecular mechanisms in CC remain unclear until the present study. Herein, we unveiled that the expression of lncRNA RP11-552M11.4 tested by qRT-PCR was enhanced in tumor tissues compared with the para-carcinoma tissues and related to FIGO Stage, lymph node metastasis, vascular invasion and distant metastasis in CC. Additionally, CC patients with high lncRNA RP11-552M11.4 level suffered from poor clinical outcomes. Moreover, silenced lncRNA RP11-552M11.4 restrained cell proliferation, migration and invasion in CC cells. Subsequently, the mechanistic studies revealed that lncRNA RP11-552M11.4 functioned as a ceRNA of ATF1 in CC by acting as the endogenous sponge for miR-3941, which was identified as a tumor suppressor in CC. Moreover, both miR-3941 inhibition and ATF1 overexpression restored the impacts of inhibited lncRNA RP11-552M11.4 on cellular processes in CC cells. Our observations elucidated the carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis, giving a new insight into the effective target for the treatment and prognosis of cervical cancer.
- Published
- 2018