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Long non-coding RNA RP11-552M11.4 favors tumorigenesis and development of cervical cancer via modulating miR-3941/ATF1 signaling
- Source :
- International journal of biological macromolecules. 130
- Publication Year :
- 2018
-
Abstract
- As one of the most aggressive malignancies, cervical cancer (CC) which mainly affects females has high risks of relapse and death. Long non-coding RNA (lncRNA) RP11-552M11.4 is verified to promote the progression of ovarian cancer; nevertheless, its role and the probable molecular mechanisms in CC remain unclear until the present study. Herein, we unveiled that the expression of lncRNA RP11-552M11.4 tested by qRT-PCR was enhanced in tumor tissues compared with the para-carcinoma tissues and related to FIGO Stage, lymph node metastasis, vascular invasion and distant metastasis in CC. Additionally, CC patients with high lncRNA RP11-552M11.4 level suffered from poor clinical outcomes. Moreover, silenced lncRNA RP11-552M11.4 restrained cell proliferation, migration and invasion in CC cells. Subsequently, the mechanistic studies revealed that lncRNA RP11-552M11.4 functioned as a ceRNA of ATF1 in CC by acting as the endogenous sponge for miR-3941, which was identified as a tumor suppressor in CC. Moreover, both miR-3941 inhibition and ATF1 overexpression restored the impacts of inhibited lncRNA RP11-552M11.4 on cellular processes in CC cells. Our observations elucidated the carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis, giving a new insight into the effective target for the treatment and prognosis of cervical cancer.
- Subjects :
- Carcinogenesis
Uterine Cervical Neoplasms
02 engineering and technology
Biology
medicine.disease_cause
Biochemistry
law.invention
03 medical and health sciences
Structural Biology
law
Cell Line, Tumor
medicine
Humans
Molecular Biology
030304 developmental biology
Cell Proliferation
0303 health sciences
ATF1
Base Sequence
Competing endogenous RNA
Cell growth
RNA
Proteins
General Medicine
Middle Aged
021001 nanoscience & nanotechnology
medicine.disease
eye diseases
Long non-coding RNA
Gene Expression Regulation, Neoplastic
MicroRNAs
Cancer research
Disease Progression
Suppressor
Female
RNA, Long Noncoding
0210 nano-technology
Ovarian cancer
Signal Transduction
Subjects
Details
- ISSN :
- 18790003
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- International journal of biological macromolecules
- Accession number :
- edsair.doi.dedup.....e556f9d564c5f319d41bd802f46ef9e9