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Your search keyword '"Sophia Loick"' showing total 3 results
Start Over Author "Sophia Loick" Topic 0302 clinical medicine
3 results on '"Sophia Loick"'

1. DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

Author

Emma Grace Bawden, Romina Zarbl, Jennifer Landsberg, Verena Sailer, Carsten Golletz, Ulrike Sailer, Friedrich Bootz, Kathrin Scheckenbach, Sophia Loick, Joern Dietrich, Glen Kristiansen, Dimo Dietrich, Timo J. Vogt, Ingela Grünwald, Andreas O. H. Gerstner, Marieta Toma, and Constanze Wiek

Subjects
0301 basic medicine, Male, HPV, Research paper, medicine.medical_treatment, lcsh:Medicine, Kaplan-Meier Estimate, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Biomarkers, Tumor, Cluster Analysis, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Indoleamine 2,3-dioxygenase 1, RNA, Messenger, Indoleamine 2,3-dioxygenase, Gene, Papillomaviridae, lcsh:R5-920, DNA methylation, Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections, lcsh:R, Head and neck squamous cell carcinoma, General Medicine, Methylation, Immunotherapy, medicine.disease, Prognosis, Head and neck squamous-cell carcinoma, Immunohistochemistry, Immune checkpoint, Gene Expression Regulation, Neoplastic, 030104 developmental biology, CpG site, 030220 oncology & carcinogenesis, Cancer research, Cytokines, CpG Islands, Female, Prediction, lcsh:Medicine (General), IDO1, Biomarker
Abstract

Background: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of the encoding gene (IDO1) in HNSCC. Methods: Methylation of three CpG sites within the promoter, promoter flank, and gene body was investigated and correlated with mRNA expression, immune cell infiltration, mutational burden, human papillomavirus (HPV)-status, and overall survival in a cohort of N = 528 HNSCC patients obtained from The Cancer Genome Atlas. In addition, IDO1 immunohistochemistry and DNA methylation analysis was performed in an independent cohort of N = 138 HNSCC samples. Findings: Significant inverse correlations of IDO1 methylation and IDO1 mRNA expression were found in the promoter and promoter flank region (Spearman's ρ = −0.163 and ρ = −0.377, respectively) while a positive correlation was present in the gene body (ρ = 0.502; all P

Published
2019

2. Comprehensive analysis of tumor necrosis factor receptor TNFRSF9 (4-1BB) DNA methylation with regard to molecular and clinicopathological features, immune infiltrates, and response prediction to immunotherapy in melanoma

Author

Jennifer Landsberg, Dennis Niebel, Emma Grace Bawden, Holger Fröhlich, Judith Sirokay, Glen Kristiansen, Friedrich Bootz, Anne Fröhlich, Sophia Loick, Gonzalo Saavedra, Simon Fietz, Romina Zarbl, Jörn Dietrich, Gerrit H. Gielen, Dimo Dietrich, Eric Diekmann, and Publica

Subjects
0301 basic medicine, Research paper, medicine.medical_treatment, MAPK, Mitogen-activated protein kinase, lcsh:Medicine, Epigenesis, Genetic, 4-1BB, 0302 clinical medicine, Gene expression, Leukocytes, Neoplasm Metastasis, Melanoma, FFPET, Formalin-fixed and paraffin-embedded tissue, lcsh:R5-920, DNA methylation, NAT, Normal adjacent tissue, MR, Mixed response, CD137, PBMCs, Peripheral blood mononucleated cells, PD-1, Programmed cell death 1, General Medicine, Methylation, Prognosis, TNFRSF9, CTLA4, Cytotoxic T-lymphocyte associated protein 4, NA, Not assessable, Gene Expression Regulation, Neoplastic, Predictive biomarker, CpG site, Immune cell infiltration, NF-kB, Nuclear factor 'kappa-light-chain-enhancer' of activated B-cells, 030220 oncology & carcinogenesis, Cytokines, IDH1, Isocitrate dehydrogenase 1, 95% CI, 95% confidence interval, Immune checkpoint, Immunotherapy, LAG3, lymphocyte activating 3, lcsh:Medicine (General), PD, Progressive disease, IRB, Institutional Review Board, MYC, MYC proto-oncogene, Prognostic biomarker, n.c., Normalized counts, Tregs, Regulatory T cells, General Biochemistry, Genetics and Molecular Biology, TILs, Tumor infiltrating lymphocytes, TPM, Transcripts per million, Interferon-gamma, Tumor Necrosis Factor Receptor Superfamily, Member 9, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, CR, Complete response, PFS, Progression-free survival, Response prediction, Biomarkers, Tumor, medicine, Humans, RNA, Messenger, PD-L1, Programmed cell death 1 ligand 1, Epigenetics, Neoplasm Staging, TNFRS9, Tumor necrosis factor receptor super family 9, business.industry, qMSP, quantitative methylation-specific PCR, lcsh:R, NK cells, Natural killer cells, PR, Partial response, HIF1-α, Hypoxia-inducible factor 1-alpha, 030104 developmental biology, Case-Control Studies, OS, Overall survival, BRAF, V-raf murine sarcoma viral oncogene homolog B1, Cancer research, TCGA, The Cancer Genome Atlas, IL-2, Interleukin 2, LHR, Likelihood Ratio, Neoplasm Grading, SKCM, Skin cutaneous melanoma, business, ARID2, AT-rich interactive domain-containing protein 2, IFN-γ, Interferon gamma, TALs, Tumor-associated lymphocytes
Abstract

EBioMedicine 52, 102647 (2020). doi:10.1016/j.ebiom.2020.102647, Published by Elsevier, Amsterdam [u.a.]

Published
2020

3. Upregulation of the long non-coding RNA CASC9 as a biomarker for squamous cell carcinoma

Author

Constanze Wiek, Michèle J. Hoffmann, Dimo Dietrich, Kathrin Scheckenbach, Johanna Droop, Wolfgang A. Schulz, Madeleine Sassenberg, Sophia Loick, and Nadine T. Gaisa

Subjects
0301 basic medicine, Cancer Research, Squamous Differentiation, Biology, lcsh:RC254-282, Sensitivity and Specificity, HNSCC, 03 medical and health sciences, 0302 clinical medicine, HOTAIR, Downregulation and upregulation, Cell Line, Tumor, Squamous cell carcinoma, Genetics, medicine, Biomarkers, Tumor, Humans, ddc:610, Aged, CASC9, Bladder cancer, Cell growth, Squamous Cell Carcinoma of Head and Neck, Gene Expression Profiling, Cancer, Biomarker, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Prognosis, Long non-coding RNA, Up-Regulation, Gene Expression Regulation, Neoplastic, stomatognathic diseases, 030104 developmental biology, Oncology, Urinary Bladder Neoplasms, Head-and-neck carcinoma, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Cancer research, Carcinoma, Squamous Cell, Biomarker (medicine), RNA, Long Noncoding, Research Article
Abstract

BMC cancer 19, 806 (2019). doi:10.1186/s12885-019-6021-6, Published by BioMed Central, London

Published
2019

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