1. Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice
- Author
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Bailong Li, Meizhou Zhu, Hu Liu, Jianming Cai, Guo Jiaming, Chen Yuanyuan, Yunhai Chuai, Fu Gao, Pei Zhang, Xiao Lei, Hainan Zhao, Pengfei Liu, Zhao Deyun, Yang Xu, and Yanyong Yang
- Subjects
Male ,0301 basic medicine ,Aging ,medicine.medical_specialty ,Article Subject ,Hematopoietic System ,Radiation induced ,Biology ,Biochemistry ,Chromosome aberration ,Open field ,Body Mass Index ,Mice ,Random Allocation ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,Sex organ ,Lymphocytes ,lcsh:QH573-671 ,Chromosome Aberrations ,Mice, Inbred BALB C ,Behavior, Animal ,lcsh:Cytology ,Low dose ,Dose-Response Relationship, Radiation ,Cell Biology ,General Medicine ,Spermatozoa ,Radiation Injuries, Experimental ,Haematopoiesis ,Dose–response relationship ,030104 developmental biology ,Endocrinology ,Immunology ,Spleen ,Whole-Body Irradiation ,Hydrogen ,Research Article ,Behavioural despair test - Abstract
Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects ofH2on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the last time of radiation exposure, all the mice were employed for the determination of the body mass (BM) observation, forced swim test (FST), the open field test (OFT), the chromosome aberration (CA), the peripheral blood cells parameters analysis, the sperm abnormality (SA), the lymphocyte transformation test (LTT), and the histopathological studies. And significant differences between the treatment group and the radiation-only groups were observed, showing thatH2could diminish the detriment induced by LDLTR and suggesting the protective efficacy ofH2in multiple systems in mice against LDLTR.
- Published
- 2016