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Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice
- Source :
- Oxidative Medicine and Cellular Longevity, Vol 2016 (2016), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects ofH2on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the last time of radiation exposure, all the mice were employed for the determination of the body mass (BM) observation, forced swim test (FST), the open field test (OFT), the chromosome aberration (CA), the peripheral blood cells parameters analysis, the sperm abnormality (SA), the lymphocyte transformation test (LTT), and the histopathological studies. And significant differences between the treatment group and the radiation-only groups were observed, showing thatH2could diminish the detriment induced by LDLTR and suggesting the protective efficacy ofH2in multiple systems in mice against LDLTR.
- Subjects :
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Article Subject
Hematopoietic System
Radiation induced
Biology
Biochemistry
Chromosome aberration
Open field
Body Mass Index
Mice
Random Allocation
03 medical and health sciences
Internal medicine
medicine
Animals
Sex organ
Lymphocytes
lcsh:QH573-671
Chromosome Aberrations
Mice, Inbred BALB C
Behavior, Animal
lcsh:Cytology
Low dose
Dose-Response Relationship, Radiation
Cell Biology
General Medicine
Spermatozoa
Radiation Injuries, Experimental
Haematopoiesis
Dose–response relationship
030104 developmental biology
Endocrinology
Immunology
Spleen
Whole-Body Irradiation
Hydrogen
Research Article
Behavioural despair test
Subjects
Details
- Language :
- English
- ISSN :
- 19420994 and 19420900
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....d48ea41c7b640538935d5fd8f56f344b