1. Prevalence of GII.4 Sydney Norovirus Strains and Associated Factors of Acute Gastroenteritis in Children: 2019/2020 Season in Guangzhou, China
- Author
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Jia Xie, Mingyong Luo, Mengru Wei, Hongyu Zhao, Xiaohan Yang, Hong Liu, Changbin Zhang, Yuan Tang, Lei Duan, and Wenli Zhan
- Subjects
0301 basic medicine ,Severe diarrhoea ,Male ,medicine.medical_specialty ,China ,Genotype ,Epidemiology ,Health, Toxicology and Mutagenesis ,viruses ,030106 microbiology ,medicine.disease_cause ,law.invention ,03 medical and health sciences ,Feces ,0302 clinical medicine ,fluids and secretions ,law ,Virology ,Internal medicine ,medicine ,Prevalence ,Humans ,030212 general & internal medicine ,Acute gastroenteritis ,Child ,Genotyping ,Polymerase chain reaction ,Phylogeny ,Caliciviridae Infections ,Original Paper ,Epidemiological characteristics ,business.industry ,Norovirus ,Winter ,virus diseases ,GII.4 Sydney ,Gastroenteritis ,RNA, Viral ,Female ,Seasons ,Gene sequence ,business ,High homology ,Food Science - Abstract
Norovirus, the leading cause of non-bacterial acute gastroenteritis (AGE) worldwide, is constantly mutating. Continuous monitoring of the evolution of epidemic genotypes and emergence of novel genotypes is, therefore, necessary. This study determined the prevalence and clinical characteristics of norovirus strains in AGE in Guangzhou, China in 2019/2020 season. This study included children aged 2–60 months diagnosed with AGE in Guangzhou Women and Children Hospital, from August 2019 to January 2020. Norovirus was detected by real-time polymerase chain reaction and clinical data were obtained. Genotyping and phylogenetic analyses were performed with partial gene sequence fragments located within the open reading frames 1 and 2. During the study period, 168 children (61.3% males) were confirmed as norovirus infectious AGE. The main symptoms were diarrhoea and vomiting and 38 patients (22.6%) had seizures. Norovirus was mainly prevalent in October and November, and GII.4 Sydney[P31] was the major genotype circulating in Guangzhou. The phylogenetic tree showed that the Guangzhou strains had high homology with the strains circulating in 2017–2019 worldwide. GII.4 Sydney was the main prevalent norovirus genotype in Guangzhou from August 2019 to January 2020, which had more severe diarrhoea than those of other genotypes. These findings provide a valuable reference for the prevention, control, and treatment of norovirus in the future.
- Published
- 2021