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Prevalence of GII.4 Sydney Norovirus Strains and Associated Factors of Acute Gastroenteritis in Children: 2019/2020 Season in Guangzhou, China
- Source :
- Food and Environmental Virology
- Publication Year :
- 2021
- Publisher :
- Springer US, 2021.
-
Abstract
- Norovirus, the leading cause of non-bacterial acute gastroenteritis (AGE) worldwide, is constantly mutating. Continuous monitoring of the evolution of epidemic genotypes and emergence of novel genotypes is, therefore, necessary. This study determined the prevalence and clinical characteristics of norovirus strains in AGE in Guangzhou, China in 2019/2020 season. This study included children aged 2–60 months diagnosed with AGE in Guangzhou Women and Children Hospital, from August 2019 to January 2020. Norovirus was detected by real-time polymerase chain reaction and clinical data were obtained. Genotyping and phylogenetic analyses were performed with partial gene sequence fragments located within the open reading frames 1 and 2. During the study period, 168 children (61.3% males) were confirmed as norovirus infectious AGE. The main symptoms were diarrhoea and vomiting and 38 patients (22.6%) had seizures. Norovirus was mainly prevalent in October and November, and GII.4 Sydney[P31] was the major genotype circulating in Guangzhou. The phylogenetic tree showed that the Guangzhou strains had high homology with the strains circulating in 2017–2019 worldwide. GII.4 Sydney was the main prevalent norovirus genotype in Guangzhou from August 2019 to January 2020, which had more severe diarrhoea than those of other genotypes. These findings provide a valuable reference for the prevention, control, and treatment of norovirus in the future.
- Subjects :
- 0301 basic medicine
Severe diarrhoea
Male
medicine.medical_specialty
China
Genotype
Epidemiology
Health, Toxicology and Mutagenesis
viruses
030106 microbiology
medicine.disease_cause
law.invention
03 medical and health sciences
Feces
0302 clinical medicine
fluids and secretions
law
Virology
Internal medicine
medicine
Prevalence
Humans
030212 general & internal medicine
Acute gastroenteritis
Child
Genotyping
Polymerase chain reaction
Phylogeny
Caliciviridae Infections
Original Paper
Epidemiological characteristics
business.industry
Norovirus
Winter
virus diseases
GII.4 Sydney
Gastroenteritis
RNA, Viral
Female
Seasons
Gene sequence
business
High homology
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 18670342 and 18670334
- Database :
- OpenAIRE
- Journal :
- Food and Environmental Virology
- Accession number :
- edsair.doi.dedup.....e321943e5b77be960f57f24c97477757