1. A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED)
- Author
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Catherine Itsiopoulos, Natalie Parletta, Bernhard T. Baune, Kerin O'Dea, Barbara J. Meyer, Svetlana Bogomolova, Anthony Villani, Jihyun Cho, Dorota Zarnowiecki, Sarah Blunden, Amy L. Wilson, Theo Niyonsenga, Leonie Segal, Parletta, Natalie, Zarnowiecki, Dorota, Cho, Jihyun, Wilson, Amy, Bogomolova, Svetlana, Villani, Anthony, Itsiopoulos, Catherine, Niyonsenga, Theo, Blunden, Sarah, Meyer, Barbara, Segal, Leonie, Baune, Bernhard T, and O'Dea, Kerin
- Subjects
Male ,Mediterranean diet ,Medicine (miscellaneous) ,Diet, Mediterranean ,fish oil ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,law ,Medicine ,030212 general & internal medicine ,intervention ,Depression (differential diagnoses) ,Uncategorized ,2. Zero hunger ,Nutrition and Dietetics ,Depression ,General Neuroscience ,food and beverages ,General Medicine ,Middle Aged ,Fish oil ,3. Good health ,Mental Health ,Treatment Outcome ,Diet quality ,depression ,Female ,omega-3 ,mental health ,Adult ,Adolescent ,omega-6 ,03 medical and health sciences ,Young Adult ,Fish Oils ,Intervention (counseling) ,Environmental health ,Fatty Acids, Omega-6 ,Fatty Acids, Omega-3 ,Humans ,Aged ,business.industry ,Mental health ,quality of life ,Dietary Supplements ,Quality of Life ,business ,030217 neurology & neurosurgery - Abstract
Objectives: We investigated whether a Mediterranean-style diet (MedDiet) supplemented with fish oil can improve mental health in adults suffering depression. Methods: Adults with self-reported depression were randomized to receive fortnightly food hampers and MedDiet cooking workshops for 3 months and fish oil supplements for 6 months, or attend social groups fortnightly for 3 months. Assessments at baseline, 3 and 6 months included mental health, quality of life (QoL) and dietary questionnaires, and blood samples for erythrocyte fatty acid analysis. Results: n = 152 eligible adults aged 18–65 were recruited (n = 95 completed 3-month and n = 85 completed 6-month assessments). At 3 months, the MedDiet group had a higher MedDiet score (t = 3.95, P < 0.01), consumed more vegetables (t = 3.95, P < 0.01), fruit (t = 2.10, P = 0.04), nuts (t = 2.29, P = 0.02), legumes (t = 2.41, P = 0.02) wholegrains (t = 2.63, P = 0.01), and vegetable diversity (t = 3.27, P < 0.01); less unhealthy snacks (t = −2.10, P = 0.04) and red meat/chicken (t = −2.13, P = 0.04). The MedDiet group had greater reduction in depression (t = −2.24, P = 0.03) and improved mental health QoL scores (t = 2.10, P = 0.04) at 3 months. Improved diet and mental health were sustained at 6 months. Reduced depression was correlated with an increased MedDiet score (r = −0.298, P = 0.01), nuts (r = −0.264, P = 0.01), and vegetable diversity (r = −0.303, P = 0.01). Other mental health improvements had similar correlations, most notably for increased vegetable diversity and legumes. There were some correlations between increased omega-3, decreased omega-6 and improved mental health. Discussion: This is one of the first randomized controlled trials to show that healthy dietary changes are achievable and, supplemented with fish oil, can improve mental health in people with depression. Refereed/Peer-reviewed
- Published
- 2023
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