1. Additive Manufacturing of Multi‐Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth
- Author
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Stefania Straino, Ruth E. Levey, Monica Salamone, James J. Prendergast, Liam Burke, Eoin D. O'Cearbhaill, Carmelo Bruno, Fergal Coulter, Kevin M. Moerman, Aoife Lowery, Ryan Paetzold, Stefano Deotti, Michael G. Monaghan, Brian S. Coulter, Gabriella Bellavia, Eimear B. Dolan, Rachel Beatty, Scott T. Robinson, Peter Dockery, Francesca Cianfarani, Garry P. Duffy, Giulio Ghersi, O'Cearbhaill, Eoin D [0000-0002-4666-5863], Apollo - University of Cambridge Repository, Coulter F.B., Levey R.E., Robinson S.T., Dolan E.B., Deotti S., Monaghan M., Dockery P., Coulter B.S., Burke L.P., Lowery A.J., Beatty R., Paetzold R., Prendergast J.J., Bellavia G., Straino S., Cianfarani F., Salamone M., Bruno C.M., Moerman K.M., Ghersi G., Duffy G.P., and O'Cearbhaill E.D.
- Subjects
Materials science ,Swine ,soft tissue implants ,medical grade silicone ,Silicones ,Biomedical Engineering ,Tissue integration ,Pharmaceutical Science ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biomaterials ,Medical grade silicone ,chemistry.chemical_compound ,Silicone ,Settore BIO/10 - Biochimica ,Materials Testing ,Animals ,Humans ,Porosity ,Implant failure ,Soft tissue ,Prostheses and Implants ,medical device coatings ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,device-tissue interaction ,Implant ,0210 nano-technology ,additive manufacturing ,Tissue ingrowth ,Biomedical engineering - Abstract
Medical devices, such as silicone-based prostheses designed for soft tissue implantation, often induce a suboptimal foreign-body response which results in a hardened avascular fibrotic capsule around the device, often leading to patient discomfort or implant failure. Here, it is proposed that additive manufacturing techniques can be used to deposit durable coatings with multiscale porosity on soft tissue implant surfaces to promote optimal tissue integration. Specifically, the “liquid rope coil effect”, is exploited via direct ink writing, to create a controlled macro open-pore architecture, including over highly curved surfaces, while adapting atomizing spray deposition of a silicone ink to create a microporous texture. The potential to tailor the degree of tissue integration and vascularization using these fabrication techniques is demonstrated through subdermal and submuscular implantation studies in rodent and porcine models respectively, illustrating the implant coating's potential applications in both traditional soft tissue prosthetics and active drug-eluting devices.
- Published
- 2021