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Additive Manufacturing of Multi‐Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth
- Source :
- Advanced Healthcare Materials. 10:2100229
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Medical devices, such as silicone-based prostheses designed for soft tissue implantation, often induce a suboptimal foreign-body response which results in a hardened avascular fibrotic capsule around the device, often leading to patient discomfort or implant failure. Here, it is proposed that additive manufacturing techniques can be used to deposit durable coatings with multiscale porosity on soft tissue implant surfaces to promote optimal tissue integration. Specifically, the “liquid rope coil effect”, is exploited via direct ink writing, to create a controlled macro open-pore architecture, including over highly curved surfaces, while adapting atomizing spray deposition of a silicone ink to create a microporous texture. The potential to tailor the degree of tissue integration and vascularization using these fabrication techniques is demonstrated through subdermal and submuscular implantation studies in rodent and porcine models respectively, illustrating the implant coating's potential applications in both traditional soft tissue prosthetics and active drug-eluting devices.
- Subjects :
- Materials science
Swine
soft tissue implants
medical grade silicone
Silicones
Biomedical Engineering
Tissue integration
Pharmaceutical Science
02 engineering and technology
010402 general chemistry
01 natural sciences
Biomaterials
Medical grade silicone
chemistry.chemical_compound
Silicone
Settore BIO/10 - Biochimica
Materials Testing
Animals
Humans
Porosity
Implant failure
Soft tissue
Prostheses and Implants
medical device coatings
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
device-tissue interaction
Implant
0210 nano-technology
additive manufacturing
Tissue ingrowth
Biomedical engineering
Subjects
Details
- ISSN :
- 21922659 and 21922640
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Advanced Healthcare Materials
- Accession number :
- edsair.doi.dedup.....61acad1bac77134c6f67a651aad86d9f