1. Reactions of Malononitrile Dimer with Isothiocyanates
- Author
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S. V. Shcherbakov, V. V. Dotsenko, Inna V. Aksenova, N. A. Aksenov, V. K. Kindop, A. A. Russkikh, A. V. Bespalov, and S. N. Ovcharov
- Subjects
chemistry.chemical_compound ,chemistry ,010405 organic chemistry ,Computational chemistry ,Dimer ,Infrared spectroscopy ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Malononitrile ,Bioavailability - Abstract
Abstract The reaction of 2-amino-1,1,3-tricyanopropene (malononitrile dimer) with isothiocyanates leads to 1-substituted 4,6-diamino-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitriles or 4,6-diamino-2-(phenylimino)-2H-thiopyran-3,5-dicarbonitrile, depending on the conditions. Quantum-chemical modeling of the IR spectra and reaction routes for the synthesized compounds was carried out. In silico predictive analysis of potential protein targets, compliance with bioavailability criteria, and ADMET parameters was performed.
- Published
- 2021